Figure 3.

Role of Na⁺ in managing PLM-mediated Ca²⁺ adaptation. A, Na⁺ responses from simulated Na⁺ clamp experiments – ISO causes Na⁺ to decrease in WT myocytes but increase in PLM-KO myocytes B, Clamping Na⁺ in WT and PLM-KO myocytes to different Na⁺ transients indicate a necessary and sufficient role for Na⁺ in conferring Ca²⁺ adaptation, evidenced by switching of the Ca²⁺ adaptation phenomena between WT and PLM-KO myocytes.