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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2012 Jan 20;52(5):1048–1055. doi: 10.1016/j.yjmcc.2011.12.015

Figure 6.

Figure 6

Opposing actions of PLB and PLM on EC coupling. A, PLB-KO myocytes also exhibit Ca2+ adaptation in spite of elevated SR load. SR load decreases with sustained β-AR stimulation. B, PLB-KO, PLM-KO myocytes do not exhibit Ca2+ exhibition. SR load does not decrease with sustained β-AR stimulation. C, PLB phosphorylation and PLM phosphorylation exert opposite effects on SR load. D, PLB phosphorylation and PLM phosphorylation exert opposite effects on cytosolic Ca2+ transients.