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Inhibition of nicotine-induced [3H]DA release from nucleus accumbens synaptosomes. Synaptosomes were perfused with buffer and then 10 μM nicotine was added as indicated by the vertical line at fraction 4. Nicotine-induced [3H]DA release was inhibited completely by 10 μM mecamylamine (a) and to a much lesser extent by 10 μM AT-1001 (b). Data shown are mean±SD from a single experiment conducted in triplicate that was repeated with similar results.
