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. 2012 Jan 25;37(6):1367–1376. doi: 10.1038/npp.2011.322

Figure 7.

Figure 7

AT-1001 reduces nicotine self-administration in rats. (a) Acute effects of AT-1001 treatment. Each data point is the mean±SEM number of rewards earned in the 1-h session following AT-1001 treatment. Filled bars represent animals responding for nicotine (30 μg/kg/inj, left axis), solid bars are animals responding for food pellets (45 mg pellets, right axis). AT-1001 doses (mg/kg, s.c.) are indicated on the x axis. *p<0.05 vs vehicle, *** p<0.001 vs vehicle. (b) AT-1001 (3 mg/kg) does not have long-lasting effects. Base is the number of reinforced responses on the day before AT-1001 treatment. Day 1 is the number of reinforced responses on the test day of AT-1001 (3 mg/kg) treatment, while day 2 is the day following the testday. *p<0.05 vs base and day 2. n=6 per group.