Figure 3.

Extinction (a) and reinstatement (b–d) of cocaine seeking in experiment 1. During extinction (panel a), high-impulsive (HI) rats were more resistant to extinction than were low-impulsive (LI) rats (session^*impulsivity: ^#p<0.05). However, in both HI and LI animals, active lever responding decreased over sessions (session: ^**p<0.001). Both HI and LI animals showed a context-induced reinstatement response (session: ^**p<0.001) and this was stronger in HI than in LI animals (panel b, session^*impulsivity: ^#p<0.05). Both cocaine (panel c, 10 mg/kg) and yohimbine (panel d, 1.25 mg/kg) induced reinstatement of cocaine seeking, but these effects did not differ between HI and LI animals (session: ^*p<0.05, ^**p<0.001).