Figure 7.

Chronic paroxetine treatment reverses long-term social fear. (a) Pre-conditioning investigation of the non-social stimulus (empty cage) during social fear conditioning (SFC; day 1; n=8 per group). Paroxetine (Par) was administered over 14 days in the drinking water (Veh) of unconditioned (uc) and conditioned (c) mice starting 1 day after SFC. (b) Investigation of non-social (ns1–ns3) and social (cages with mice; s1–s6) stimuli during extinction on day 15 (3-min exposure to stimulus, 3-min inter-exposure interval). (c) Investigation of social stimuli (s1–s6) during extinction recall on day 16. Data represent mean percentage of investigation time±SEM. ^*p<0.05 vs the other three groups.