Table 3. Behavioral Changes Indicating Social Fear After Social Fear Conditioning.
Decreased SI | Freezing | Stretched approaches | Defensive burying | |
---|---|---|---|---|
Short-term social fear (Figure 1) | 92.3 % (12/13) | 61.5 % (8/13) | 61.5 % (8/13) | 38.5 % (5/13) |
Long-term social fear (Figure 2) | 100 % (8/9) | 88.9 (8/9) | 55.6 % (5/9) | 22.2 (2/9) |
Fear of novelty (Figure 4) | 100 % (8/8) | 75 % (6/8) | 50 % (4/8) | 0 % (0/8) |
Foot-shock exposure (Figure 5) | 0 % (0/8) | 0 % (0/8) | 12.5 5 (1/8) | 0 % (0/8) |
Short-term social fear by diazepam (Figure 6) | 90 % (9/10) | 90 % (9/10) | 80 % (8/10) | 30 % (3/10) |
Long-term social fear by paroxetine (Figure 7) | 100 % (8/8) | 75 % (6/8) | 75 % (6/8) | 75 % (6/8) |
Decreased social investigation (SI) represents the percentage of conditioned mice in each experiment that showed a decrease of at least 50% in investigation of the first social stimulus compared with the mean of their respective unconditioned mice during extinction. Freezing, stretched approaches, and defensive burying represent the percentage of conditioned mice that showed those behaviors when the social stimuli were in their home cage during extinction. None of the unconditioned mice showed these behaviors. Data from Figures 6 and 7 include only conditioned vehicle-treated mice.