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Alteration of platinum bound to DNA by sodium arsenite and hyperthermia. A2780, A2780/CP70, and SKOV-3 cells were treated with 40μM cisplatin for 1 h at 37°C or 39°C. Total genomic DNA was isolated at 0 (immediately) and 24 h after treatment for platinum bound to DNA determination. Data are means ± SD of three independent experiments. p < 0.05; *compared with CP37 0 h, # compared with CP39 0 h, † compared with CP37 24 h, and ¥ compared with CP39 24 h.
