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. 2012 Mar 29;106(8):1395–1405. doi: 10.1038/bjc.2012.81

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Copyright © 2012 Cancer Research UK

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β-Catenin genotype did not alter chemosensitivity towards chemotherapeutic drugs. By high throughput screening, chemotherapeutic drugs were applied in 18 different concentrations to HCT116, HAB-68^mut and HAB-92^wt cells (for IC₅₀ and for additional drugs see Table 1). Treatment responses of these cell lines towards the MDR-associated drugs adriamycin (A), paclitaxel (B), vincristine (C), etoposide (D), mitoxanthrone (E) and topotecan (F), as well as towards the chemotherapeutics melphalan (G) and 5-fluorouracil (H) are shown. Chemosensitivity of HCT116, HAB-68^mut and HAB-92^wt cells did not differ despite their differences in β-catenin genotype and ABCB1 expression levels. Cell survival is expressed as percent of control growth. Values are given as averages of triplicates.