Figure 2. Ivermectin is a broad-spectrum Impα/β1 inhibitor that does not affect other nuclear import pathways.

HeLa cells transfected to express the indicated GFP-fusion proteins were treated with or without 25 μM ivermectin for 1 h before live-cell imaging 24 h after transfection. Results (mean±S.E.M., n>68) were determined as described in Figure 1(B); **P<0.001.