Table 1.
Vitamin B12, folate, and related metabolites in serum of B12-deficient rats
| Control | Deficient | P Value | |
|---|---|---|---|
| Serum | |||
| B12, pg/ml | 1,041.33 ± 62.30 | 426.5 ± 77.84* | <0.001 |
| Folate, ng/ml | 65.48 ± 17.35 | 82.25 ± 12.99 | 0.087 |
| Hcy, μM | 6.85 ± 0.72 | 31.07 ± 2.77* | <0.001 |
| MMA, μM | 0.18 ± 0.05 | 5.11 ± 3.24* | 0.004 |
| Brain | |||
| B12, ng/g | 45.71 ± 3.27 | 17.51 ± 1.60* | <0.001 |
| SAM, nmol/g | 29.80 ± 1.44 | 26.22 ± 1.12* | <0.001 |
| SAH, nmol/g | 1.06 ± 0.08 | 1.09 ± 0.13 | 0.643 |
| SAM/SAH | 28.04 ± 1.59 | 24.18 ± 2.99* | 0.019 |
| Liver | |||
| Vitamin B12, ng/g | 38.25 ± 4.44 | 6.07 ± 0.79* | <0.001 |
| SAM, nmol/g | 79.50 ± 23.96 | 55.40 ± 4.66* | 0.036 |
| SAH, nmol/g | 13.24 ± 3.37 | 14.81 ± 0.83 | 0.294 |
| SAM/SAH | 6.27 ± 1.94 | 3.75 ± 0.39* | 0.011 |
Data are given as means ± SD (n = 6). Hcy, homocysteine; MMA, methylmalonic acid; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine.
*
Significant difference (P < 0.05).