Fig. 6.

Fusion of mouse, rat, and human islet ATP proction/insulin secretion diagrams and comparison with corresponding published data obtained with 2 functionally diverging β-cell lines (44, 52). A: secretion profiles of mouse, rat, and human islets as a function of the glucose concentration. B: combined energy production/insulin secretion curve with data on ATP production and insulin release from all 3 types of islets projected on 1 single continuous sigmoidal curve (note that results with 20–30 μM piragliatin in Fig. 1 were not included because respiration and glucose metabolism were inhibited at these high levels). C and D: analogous sets of data from 2 tumorous β-cell lines (44).