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Piragliatin repairs defective insulin release, oxygen consumption, and calcium responses to glucose of islets isolated from type 2 diabetic organ donors. A: insulin release (n = 3). B: oxygen consumption for the same experiments presented in A (n = 3). C: comparison of OCR glucose dependencies of healthy islets and those of diabetics and of the effect of piragliatin on these 2 sets of islets. D: GKA effect on intracellular calcium concentrations.
