Developmental expression of the BAP111 protein. (A) Ten
micrograms of protein extracted from staged embryos (0–2, 2–4, 4–8,
8–12, and 12–22 h), larvae (L), pupae (P), and adult females
(♀) or males (♂) was analyzed by Western blotting
with anti-BRM and anti-BAP111 antibodies. Blots are overexposed to
reveal the signal in larvae. (B) Affinity-purified
anti-BAP111 antibodies detect ubiquitous nuclear staining of BAP111 in
syncytial blastoderm embryos (Upper) and germ band
retracted embryos (Lower). (C) BAP111 is
not associated with mitotic chromosomes. Higher magnification (630×)
view of a cephalic-furrow stage embryo stained with BAP111 antibodies
(green) and propidium iodide to visualize DNA (red). BAP111 is nuclear
except in domains of mitotic activity where BAP111 becomes dispersed
throughout the cell.