Table 2.
Phenotypic, genetic, and environmental correlations between WM/GM contrast and cortical thickness
| Region of Interest | Phenotypic Correlations | Genetic Correlations | Unique Environment Correlation | p-values | |||||
|---|---|---|---|---|---|---|---|---|---|
| rp | 95% CI | rg | 95% CI | re | 95% CI | No rp | No rg | No re | |
| Frontal Lobe | |||||||||
| Superior Frontal Gyrus-L | −.05 | (−.16; .06) | −.16 | (−.34; .01) | .18 | (.00; .34) | .0682 | .0668 | .0463 |
| Superior Frontal Gyrus-R | −.03 | (−.14; .08) | −.17 | (−.35; .01) | .22 | (.05; .38) | .0271 | .0689 | .0113 |
| Middle Frontal Gyrus | |||||||||
| Rostral division-L | .04 | (−.06; .15) | .10 | (−.18; .37) | .00 | (−.17; .17) | .7047 | .4839 | 1.000 |
| Rostral division-R | .02 | (−.08; .13) | −.09 | (−.34; .15) | .14 | (−.03; .30) | .2894 | .4424 | .1153 |
| Caudal division-L | .00 | (−.11; .11) | −.20 | (−.42; .01) | .27 | (.10; .42) | .0083 | .0644 | .0022 |
| Caudal division-R | −.01 | (−.11; .10) | −.17 | (−.38; .03) | .23 | (.06; .39) | .0253 | .0949 | .0080 |
| Inferior Frontal Gyrus | |||||||||
| Pars opercularis-L | .18 | (.07; .28) | .04 | (−.18; .25) | .36 | (.20; .50) | <.0001 | .6985 | <.0001 |
| Pars opercularis-R | .18 | (.08; .28) | .09 | (−.23; .38) | .23 | (.07; .38) | .0005 | .5485 | .0045 |
| Pars triangularis-L | .07 | (−.03; .18) | .13 | (−.16; .40) | .03 | (−.13; .20) | .3734 | .3652 | .6985 |
| Pars triangularis-R | .06 | (−.04; .16) | −.02 | (−.35; .28) | .12 | (−.05; .28) | .2645 | .8875 | .1573 |
| Pars orbitalis-L | −.22 | (−.31; −.12) | −.27 | (−.59; .09) | −.19 | (−.34; −.03) | .0001 | .1269 | .0221 |
| Pars orbitalis-R | −.11 | (−.21; −.01) | −.14 | (−.43; .17) | −.10 | (−.26; .08) | .0876 | .3681 | .2815 |
| Orbitofrontal Cortex | |||||||||
| Lateral division-L | −.15 | (−.25; −.05) | −.24 | (−.48; .01) | −.07 | (−.24; .10) | .0177 | .0599 | .4274 |
| Lateral division-R | −.09 | (−.19; .02) | −.19 | (−.43; .06) | .01 | (−.17; .18) | .2276 | .1416 | .9203 |
| Medial division-L | −.28 | (−.37; −.19) | −.24 | (−.50; .10) | −.31 | (−.46; −.16) | <.0001 | .1463 | .0001 |
| Medial division-R | −.40 | (−.48; −.31) | −.64 | (−.86; −.42) | −.20 | (−.35; −.03) | <.0001 | <.0001 | .0210 |
| Frontal pole-L | −.19 | (−.28; −.09) | −.24 | (−.68; .24) | −.17 | (−.32; .00) | .0011 | .2857 | .0447 |
| Frontal pole-R | −.25 | (−.34; −.15) | .05 | (−1.0; 1.0) | −.31 | (−.45; −.16) | <.0001 | .8875 | .0001 |
| Precentral gyrus-L | −.15 | (−.25; −.04) | −.25 | (−.42; −.07) | .05 | (−.13; .22) | .0216 | .0069 | .5902 |
| Precentral gyrus-R | −.18 | (−.29; −.07) | −.33 | (−.50; −.15) | .10 | (−.08; .27) | .0016 | .0004 | .2857 |
| Paracentral lobule-L | −.16 | (−.26; −.06) | −.32 | (−.55; −.08) | .00 | (−.17; .17) | .0082 | .0081 | 1.000 |
| Paracentral lobule-R | −.23 | (−.33; −.13) | −.33 | (−.52; −.13) | −.11 | (−.28; .06) | .0001 | .0020 | .2031 |
| Cingulate Cortex | |||||||||
| Rostral anterior cingulate-L | −.20 | (−.29; −.10) | −.37 | (−.81; .07) | −.13 | (−.28; .04) | .0006 | .0897 | .1237 |
| Rostral anterior cingulate-R | −.23 | (−.32; −.13) | −.13 | (−.48; .32) | −.27 | (−.40; −.11) | <.0001 | .5023 | .0007 |
| Caudal anterior cingulate-L | −.45 | (−.53; −.37) | −.57 | (−.87; −.15) | −.41 | (−.53; −.27) | <.0001 | .0186 | <.0001 |
| Caudal anterior cingulate-R | −.35 | (−.44; −.26) | −.62 | (−1.0; −.19) | −.26 | (−.41; −.10) | <.0001 | .0126 | .0021 |
| Rostral posterior division-L | −.01 | (−.11; .09) | .09 | (−.30; .52) | −.06 | (−.21; .11) | .7945 | .6315 | .5023 |
| Rostral posterior division-R | −.10 | (−.21; .00) | −.28 | (−.59; .02) | .01 | (−.16; .17) | .0963 | .0668 | .9203 |
| Retrosplenial cortex-L | −.05 | (−.15; .06) | .05 | (−.25; .37) | −.11 | (−.27; .05) | .3465 | .7401 | .1703 |
| Retrosplenial cortex-R | −.17 | (−.26; −.07) | −.30 | (−.60; .00) | −.09 | (−.24; .08) | .0054 | .0472 | .2965 |
| Parietal Lobe | |||||||||
| Postcentral gyrus-L | −.06 | (−.17; .05) | −.20 | (−.40; .00) | .14 | (−.04; .30) | .1142 | .0528 | .1183 |
| Postcentral gyrus-R | −.22 | (−.32; −.11) | −.34 | (−.52; −.14) | −.06 | (−.23; .11) | .0003 | .0012 | .4976 |
| Supramarginal gyrus-L | .20 | (.10; .30) | .05 | (−.20; .26) | .36 | (.21; .50) | <.0001 | .6892 | <.0001 |
| Supramarginal gyrus-R | .15 | (.05; .25) | .03 | (−.25; .28) | .25 | (.09; .40) | .0011 | .8065 | .0027 |
| Superior parietal cortex-L | −.02 | (−.13; .09) | −.24 | (−.46; −.03) | .29 | (.12; .44) | .0028 | .0216 | .0010 |
| Superior parietal cortex-R | .06 | (−.05; .17) | −.07 | (−.28; .14) | .25 | (.07; .41) | .0171 | .5220 | .0059 |
| Inferior parietal cortex-L | .16 | (.05; .26) | .10 | (−.14; .33) | .23 | (.05; .39) | .0017 | .3897 | .0104 |
| Inferior parietal cortex-R | .20 | (.10; .30) | .17 | (−.09; .40) | .23 | (.07; .39) | .0001 | .1990 | .0061 |
| Precuneus-L | .15 | (.04; .25) | −.01 | (−.25; .22) | .33 | (.17; .47) | .0001 | 1.000 | .0001 |
| Precuneus-R | .18 | (.07; .28) | .09 | (−.15; .31) | .27 | (.11; .42) | .0002 | .4348 | .0014 |
| Occipital Lobe | |||||||||
| Lingual gyrus-L | −.21 | (−.31; −.11) | −.20 | (−.41; .03) | −.23 | (−.39; −.06) | .0001 | .0853 | .0072 |
| Lingual gyrus-R | −.18 | (−.28; −.07) | −.34 | (−.55; −.14) | .04 | (−.13; .21) | .0027 | .0011 | .6171 |
| Pericalcarine cortex-L | −.52 | (−.59; −.44) | −.68 | (−.86; −.48) | −.39 | (−.53; −.24) | <.0001 | <.0001 | <.0001 |
| Pericalcarine cortex-R | −.54 | (−.61; −.47) | −.89 | (−1.0; −.68) | −.34 | (−.47; −.19) | <.0001 | <.0001 | <.0001 |
| Cuneus-L | −.10 | (−.21; .00) | −.06 | (−.28; .17) | −.16 | (−.32; .01) | .0550 | .6242 | .0706 |
| Cuneus-R | −.25 | (−.35; −.15) | −.18 | (−.37; .04) | −.34 | (−.48; −.18) | <.0001 | .1096 | .0001 |
| Lateral occipital cortex-L | −.21 | (−.31; −.11) | −.19 | (−.39; .02) | −.23 | (−.39; −.06) | .0001 | .0680 | .0071 |
| Lateral occipital cortex-R | −.16 | (−.27; −.06) | −.20 | (−.41; .03) | −.13 | (−.29; .04) | .0064 | .0864 | .1354 |
| Temporal Lobe | |||||||||
| Lateral Aspect | |||||||||
| Superior temporal gyrus-L | .04 | (−.07; .14) | −.07 | (−.34; .20) | .13 | (−.04; .30) | .2967 | .6101 | .1302 |
| Superior temporal gyrus-R | .10 | (−.01; .20) | .03 | (−.22; .27) | .17 | (.00; .33) | .0542 | .8065 | .0460 |
| Middle temporal gyrus-L | .17 | (.07; .27) | .25 | (−.04; .53) | .11 | (−.06; .27) | .0049 | .0848 | .1897 |
| Middle temporal gyrus-R | .10 | (−.01; .20) | −.07 | (−.39; .22) | .21 | (.04; .37) | .0253 | .6315 | .0140 |
| Inferior temporal gyrus-L | .06 | (−.04; .17) | .02 | (−.29; .29) | .10 | (−.07; .26) | .3499 | .8875 | .2636 |
| Inferior temporal gyrus-R | −.03 | (−.13; .08) | −.05 | (−.31; .21) | −.01 | (−.17; .15) | .8825 | .7184 | .9203 |
| Transverse temporal cortex-L | −.16 | (−.26; −.06) | −.22 | (−.51; .09) | −.14 | (−.30; .04) | .0055 | .1583 | .1245 |
| Transverse temporal cortex-R | −.11 | (−.22; −.01) | −.27 | (−.56; .01) | .00 | (−.17; .16) | .0696 | .0538 | 1.000 |
| Banks sup. temporal sulcus-L | −.06 | (−.16; .04) | .07 | (−1.0; 1.0) | −.08 | (−.24; .08) | .4296 | .8875 | .3009 |
| Banks sup. temporal sulcus-R | .09 | (−.01; .19) | .02 | (−.68; .67) | .11 | (−.05; .26) | .1800 | 1.000 | .1809 |
| Medial Aspect | |||||||||
| Entorhinal cortex-L | −.31 | (−.40; −.22) | −.47 | (−.93; −.03) | −.26 | (−.40; −.10) | <.0001 | .0393 | .0016 |
| Entorhinal cortex-R | −.32 | (−.41; −.23) | −.58 | (−1.0; −.17) | −.22 | (−.37; −.06) | <.0001 | .0100 | .0066 |
| Parahippocampal cortex-L | −.16 | (−.26; −.05) | −.18 | (−.46; .12) | −.14 | (−.30; .03) | .0083 | .2146 | .1029 |
| Parahippocampal cortex-R | −.17 | (−.27; −.07) | −.29 | (−.52; −.05) | −.07 | (−.23; .10) | .0041 | .0198 | .4062 |
| Temporal pole-L | −.21 | (−.30; −.11) | −.33 | (−.62; −.04) | −.13 | (−.29; .04) | .0003 | .0275 | .1245 |
| Temporal pole-R | −.04 | (−.14; .06) | .20 | (−.25; .80) | −.12 | (−.28; .04) | .3296 | .3802 | .1371 |
| Fusiform gyrus-L | .08 | (−.02; .18) | .10 | (−.17; .36) | .07 | (−.10; .23) | .2982 | .4751 | .4424 |
| Fusiform gyrus-R | .05 | (−.06; .15) | −.13 | (−.39; .12) | .22 | (.05; .37) | .0408 | .3149 | .0122 |
rp = phenotypic correlation; rg= genetic correlation; re= unique environment correlation; No rp = test of no phenotypic correlation between estimates of WM/GM contrast and cortical thickness; No rg = test of no genetic correlation; No re = test of no unique environment correlation.