Figure 4.

Increasing working memory demand is associated with an increase in hippocampal activity when complex, but not simple, spatial stimuli are presented Lee and Rudebeck (2010b). Participants were required to carry out a one-back (A) or two-back (B) working memory task in an MRI scanner, involving simple spatial arrays or complex virtual reality rooms (red arrow indicates one-back repetition target, blue arrow indicates two-back repetition target). The pattern of activity observed in the right posterior hippocampus is illustrated in (C) (activity rendered on the MNI152 template at p < 0.05 family wise error corrected for multiple comparisons with a small volume correction for the medial temporal lobe).