Skip to main content
. 2012 May 15;139(10):1821–1830. doi: 10.1242/dev.075796

Fig. 1.

Fig. 1.

Cleft lip with cleft palate (CL/P) and craniofacial skeletal defects in Wnt9b–/– mice. (A,B) Front facial views of wild-type and Wnt9b–/– fetuses at E18.5. Arrows indicate the bilateral cleft lip. (C,D) Ventral view of the lip and palate in E18.5 fetuses. The lower jaw was removed for a better view of the palate. Cleft of the secondary palate is indicated by arrows. (E,F) Coronal sections of the facial region of E14.5 embryos. Arrow indicates cleft of the secondary palate. (G-L) Lateral (G,H) and ventral (I-L) views of wild-type and Wnt9b–/– skulls at E18.5. The mandible was removed for a better view of the skull in I-L. The pmx bone is well developed in wild-type mice, whereas Wnt9b–/– pmx bone is underdeveloped and separated into two pieces due to cleft lip (arrowheads). mc, Meckel’s cartilage; mx, maxillar; ns, nasal septum; pmx, premaxilla; ppmx, palatal process of maxilla; pppx, palatal process of premaxilla; ps, palatal shelf; t, tongue.