Table 4.

Associations between ET-only and EPT Use and Lung Cancer Risk by Smoking Status, NIH-AARP Diet and Health Study Cohort

	Never Smoker (n= 53,953)				Former Smoker (n= 47,800)				Current Smoker (n= 16,255)
	No. cancers	RR	95% CI		No. cancers	RR	95% CI		No. cancers	RR	95% CI
ET only use - All women
No	72	1.00	reference		354	1.00	reference		457	1.00	reference
Yes	49	0.90	0.59	1.38	280	0.95	0.79	1.14	292	1.00	0.85	1.18
p-value for trend			0.66				0.44				0.76
Receny of use
Former	14	0.97	0.54	1.75	76	0.84	0.65	1.09	111	1.10	0.89	1.37
Current	35	0.88	0.55	1.41	199	0.99	0.81	1.22	178	0.95	0.78	1.16
p-value for trend			0.63				0.77				0.43
Duration of use (y)
<5	9	0.55	0.27	1.11	94	1.03	0.81	1.30	105	1.01	0.81	1.26
5–9	8	1.00	0.46	2.17	38	0.89	0.63	1.26	46	1.20	0.88	1.65
≥10	30	1.07	0.65	1.79	146	0.90	0.72	1.13	137	0.95	0.76	1.18
p-value for trend			0.58				0.22				0.53
	Never Smoker (n= 30,473)				Former Smoker (n=27,518)				Current Smoker (n= 9,590)
	No. cancers	RR	95% CI		No. cancers	RR	95% CI		No. cancers	RR	95% CI
EPT use - Women with intact uteri
No	54	1.00	reference		263	1.00	reference		339	1.00	reference
Yes	28	0.85	0.53	1.38	180	0.98	0.81	1.20	173	1.14	0.94	1.38
p-value for trend			0.56				0.87				0.17
Recency of use
Former	6	0.78	0.34	1.83	54	1.20	0.89	1.61	49	1.27	0.94	1.72
Current	21	0.85	0.50	1.45	124	0.91	0.73	1.14	121	1.09	0.88	1.35
p-value for trend			0.54				0.54				0.34
Duration of use (y)
<5	10	0.75	0.37	1.49	78	1.07	0.83	1.39	77	1.25	0.97	1.61
5–9	6	0.65	0.27	1.55	39	0.77	0.55	1.09	40	0.97	0.69	1.35
≥10	11	1.17	0.60	2.30	59	1.06	0.79	1.42	53	1.18	0.88	1.58
p-value for trend			0.98				0.83				0.28

RR adjusted for age, race, age at menarche, menopausal type and age, BMI, emphysema diagnosis, cigarette smoking status and number of cigarettes/day, and other hormone therapy formulations.