Skip to main content
. Author manuscript; available in PMC: 2012 Apr 17.
Published in final edited form as: Nature. 2010 Jun 3;465(7298):577–583. doi: 10.1038/nature09141

Figure 3. The antiapoptotic function of HIF-1 is mediated by a concerted action of TYR-2 and TYR-3.

Figure 3

a, Wild-type or vhl-1(ok161) worms were grown on bacteria containing either an empty control RNAi vector or the HIF-1β homologue aha-1(RNAi) beginning at the third larval stage (L3). Synchronized young adult animals were irradiated and germline apoptosis was quantified at the indicated time points. Data shown represent the average of three independent experiments ± s.d. (n > 20 per time point and experiment). b–d, Time-course analysis of germ cell apoptosis in synchronized control or irradiated young adult animals. Data shown represent the average of three to six independent experiments ± s.d. (n > 20). e, Western blot analysis of CEP-1 in synchronized young adult worms. β-actin was used as loading control. f, Analysis of germ cell apoptosis in unirradiated synchronized animals 48 h after L4 stage. Data shown represent the average of three independent experiments ± s.d. (n > 20).