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. Author manuscript; available in PMC: 2012 Apr 17.
Published in final edited form as: Nature. 2010 Jun 3;465(7298):577–583. doi: 10.1038/nature09141

Figure 4. HIF-1 drives tyr-2 expression in ASJ neurons.

Figure 4

a, Transcriptional tyr-2 GFP-reporter opIs216[Ptyr-2::gfp] in a vhl-1(ok161) mutant background reveals HIF-1-dependent expression in two neurons in the head. Arrowheads indicate the dendritic extensions to the anterior end of the worm. Arrows indicate axons that are associated with the nerve ring. Scale bar, 20 µm. b–g, DiD staining in opIs216[Ptyr-2::gfp]; vhl-1(ok161) reveals that the GFP signal co-localizes with the most ventro-posterior amphid neurons, the ASJL and ASJR sensory neurons. Scale bars, 10 µm.