. Author manuscript; available in PMC: 2012 Apr 17.

Published in final edited form as: Nat Rev Cardiol. 2010 Oct 26;7(12):686–698. doi: 10.1038/nrcardio.2010.161

Table 4. Epidemiological studies of hypotension and cognitive decline.

Study name	n, age (years)	Follow-up (years)	Outcomes	BP measures	Covariates	Associations with cognitive tasks
ARIC⁸⁴	12,702, 50–60	12	Neuropsychological tests	OH, HTN	D, E, RF	OH associated with worse cognition (Digit Symbol Substitution and Word Fluency tests)
MPP⁸⁶	722 men, 50–55	20	Cardiac disease stroke, mortality	OH, HTN	D, RF	OH associated with increased age, low body mass, HTN, antihypertensive treatment, DM, smoking, coronary events, stroke, and all-cause mortality
Helsinki Ageing Study⁸⁷	650, 75–85	10	MMSE	OH, HTN	D, RF	Low BP associated with MMSE <24; HTN unrelated to cognition

Abbreviations: ARIC, Atherosclerosis Risk in Communities; BP, blood pressure; D, demographic variables; DM, diabetes mellitus; E, education; HTN, hypertension; OH, orthostatic hypotension; MPP, Malmö Preventive Project; MMSE, minimental state examination; RF, risk factors (BMI, DM, HTN, cholesterol, smoking).