Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Apr 9;209(4):837–854. doi: 10.1084/jem.20112285

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 Hung et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 2. — Cu^II(atsm) is neuroprotective in multiple animal models of PD. (a) C57BL/6 mice were lesioned with MPTP (40 mg/kg i.p.). The SNpc count (dotted line) was determined 24 h after MPTP lesioning (when drug treatment commenced). Effect of treatment with Cu^II(atsm) at both 15 and 30 mg/kg on the survival of SNpc dopaminergic neurons 20 d after lesioning. (b) C57BL/6 mice were lesioned unilaterally with 6-OHDA (intranigral dose). Effect of treatment with 30 mg/kg of Cu^II(atsm) on the survival of SNpc dopaminergic neurons. (c) Effect of Cu^II(atsm) (30 mg/kg) treatment of mice overexpressing human A53T (hA53T) α-synuclein, either nonlesioned or lesioned with MPTP on the survival of SNpc dopaminergic neurons. All data are expressed as mean ± SEM; for statistical analysis, one-way ANOVA was performed with a Dunnett post-doc analysis for multisample testing using untreated MPTP-lesioned mice (a), hA53T tg untreated or MPTP-lesioned untreated hA53T tg mice (c), and Student’s t test for two-sample testing (b) as controls. *, P < 0.05; **, P < 0.01; ***, P < 0.001.