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. 2012 Apr 9;209(4):837–854. doi: 10.1084/jem.20112285

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© 2012 Hung et al.

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Figure 4. — Cu^II(atsm) treatment increases TH and dopamine. (a) Sections of SNpc stained for TH from unlesioned and MPTP-lesioned mice treated with vehicle, 15 mg/kg Cu^II(atsm), or 30 mg/kg Cu^II(atsm). Results were confirmed by stereological counting (b) and Western blotting (c and d). (e) TH results were also confirmed by qPCR. (f) Dopamine levels in Cu^II(atsm)-treated lesioned animals compared with control lesioned animals. Dopamine levels are expressed relative to tissue weight. All data are expressed as mean ± SEM; for statistical analysis, one-way ANOVA was performed with a Dunnett post-hoc analysis for multisample testing using MPTP-lesioned untreated mice as controls. *, P < 0.05; **, P < 0.01; ***, P < 0001. Bars, 250 µm.