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. 2012 Apr 9;209(4):641–651. doi: 10.1084/jem.20112071

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© 2012 Okoye et al.

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Figure 4. — CD4⁺ T_N deficiency does not accelerate disease progression. (A) Kaplan-Meier plot of the time to end-stage AIDS (day of disease mandated necropsy) for CD4⁺ T_N-depleted (red, n = 9) versus -repleted RMs (blue, n = 9) over the 1 yr of follow-up. Log rank analysis indicated that rate of progression to AIDS between the two groups was not significantly different (P = 0.72). (B) Major pathological findings at necropsy of study RMs progressing to end-stage AIDS (n = 5 and 4 for CD4⁺ T_N-depleted vs. -repleted RMs, respectively). (C) Flow cytometric profiles (as described in Fig. 1 M) of CD4⁺ T cell populations in blood and various LNs at necropsy of representative CD4⁺ T_N-depleted (#24273, progression to AIDS at day 190 pi) and CD4⁺ T_N-repleted (#25522, progression to AIDS at day 163 pi) RMs. The percentage of T_N of gated events (total CD4⁺ T) is shown in red in the bottom left. The percentage of CD4⁺ of total T cells is shown in black at the top right. (D) Comparison of CD4⁺/CD8⁺ ratios within the T_M populations in blood and selected secondary lymphoid tissues (axillary and inguinal LNs and spleen) and effector sites (liver, BAL, and small intestinal mucosa) of four of five CD4⁺ T_N-depleted (red) and four of four CD4⁺ T_N-repleted (blue) RMs studied at necropsy (one CD4⁺ T_N-depleted RM could not be analyzed as a result of inadequate staining of cell preparations obtained at necropsy). Shown are box plots, with boxes and whiskers indicating interquartile ranges (25^th–75^th percentiles) and 10^th–90^th percentile values, respectively. Statistical analysis of differences in this parameter between groups was analyzed as described in the Materials and methods (NS, nonsignificant).