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. Author manuscript; available in PMC: 2013 Feb 23.
Published in final edited form as: J Med Chem. 2012 Feb 10;55(4):1526–1537. doi: 10.1021/jm201265f

Figure 7.

Figure 7

Comparison of inhibition frequencies between kinase domain or active site identity groups. (A) Average F values for incrementally binned identity groups were plotted for either the full kinase domain or active site residues. (B) The crystal structures and pseudosequence of residues within 6 Å of an ATP analog (green) aligned for PKA, AKT2, and AURKA. Homology maps generated using a percent identity cutoff that results in the formation of nine groups for the (C) kinase domain and (D) active site residues.