Figure 1. 3T and 7T MRI in ALS and healthy control.

3T and 7T brain MRI signal changes in the motor cortex hand knob differed between ALS patients (A, B, C) and healthy controls (D, E, F). Cortical hypointensity (arrows) is shown to be present in an ALS patient (Patient 2, age 51) and not in a healthy control on 3T FLAIR (A, D) and 7T gradient echo magnitude images (B, E). These areas corresponded to hyperintensity in the 7T R₂ ^* maps (C, F). Scale bar represents R₂ ^* value in Hz.