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. 2012 Apr 17;7(4):e35241. doi: 10.1371/journal.pone.0035241

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(A) Higher grades of hypointensity in the hand knob region on 3T FLAIR MRI occurred with greater frequency in ALS patients (black bars) than in healthy controls (gray bars). (B) Higher grades of hypointensity on 3T FLAIR MRI was associated with higher upper motor neuron impairment score (UMN-IS). Each dot represents the grade for one hemisphere and the UMN-IS score for the contralateral limb. Line indicates mean for group. Hypointensity was rated grade 0 (absent), grade 1 (present, mild), and grade 2 (present, marked). The UMN-IS is graded from 0–5 with normal function = 0, and higher scores indicating greater UMN impairment.