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. 2012 Apr 17;7(4):e34357. doi: 10.1371/journal.pone.0034357

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Barrett et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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a) Electron density profile of Sample 1 (100% DMPC) . b) The position of the ASA molecule can be determined from the electron densities of Sample 2 (1mol% ASA) and Sample 3 (5mol% ASA). The ASA molecule can be placed in the head group region of the bilayer, at values of 16 Å21 Å, with the hydrophilic oxygen groups at a position of 21 Å, pointing towards the hydration water. c) By comparing electron densities of Sample 3 and Sample 11 the position of the cholesterol molecule can be determined. Cholesterol and ASA molecules co-exist in saturated lipid bilayers and cholesterol most likely takes an upright position with the hydrophilic head pointing towards the aqueous environment. DMPC, ASA and cholesterol molecules are drawn to visualize the most likely positions and orientations.

Inline graphic — a) Electron density profile of Sample 1 (100% DMPC) . b) The position of the ASA molecule can be determined from the electron densities of Sample 2 (1mol% ASA) and Sample 3 (5mol% ASA). The ASA molecule can be placed in the head group region of the bilayer, at values of 16 Å21 Å, with the hydrophilic oxygen groups at a position of 21 Å, pointing towards the hydration water. c) By comparing electron densities of Sample 3 and Sample 11 the position of the cholesterol molecule can be determined. Cholesterol and ASA molecules co-exist in saturated lipid bilayers and cholesterol most likely takes an upright position with the hydrophilic head pointing towards the aqueous environment. DMPC, ASA and cholesterol molecules are drawn to visualize the most likely positions and orientations.