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Cell proliferation and IFN-γ production in vitro. Mice were infected by aerosol with either M. tuberculosis NHN5 (filled bar) or HN878 (open bar). Proliferation in response to H37Ra sonicate was measured by [3H]thymidine incorporation (Top and Bottom). IFN-γ release by spleen cells was measured by ELISA (Middle). All results are from one representative experiment with 10 mice per group per time point.
