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Survival and bacterial load in lungs of B6D2/F1 mice infected with M. tuberculosis. Mice were infected by aerosol with 2.3 log10 HN878 and treated intranasally with IFN-α/β (■; A and C) or IFN-γ (▴; B and D), or untreated (□). (A and B) Survival of mice (11 mice per experimental group). (C and D) Growth of HN878 in lungs of cytokine-treated (filled symbols) or untreated (open symbols) aerosol-infected mice over 28 days. Results are means of three to four mice per group per time point.
