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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Neurobiol Aging. 2012 Jan 14;33(7):1483.e25–1483.e30. doi: 10.1016/j.neurobiolaging.2011.12.018

Figure 3. Immuno-EM localization of Klotho.

Figure 3

A–B. Klotho immunogold particles indicate strong signals at the inner portion of the nuclear envelop and the nucleolus of choroid plexus cells. The less-intense immunoreactive signal is also observed at the cell surface (arrows in A and B). Arrowheads point to the nuclear membrane in panel A. C–D. Immunogold particles label Klotho in the peripheral portion of the nucleus and in the nucleolus of Purkinje cells. E. Immunogold particles label Klotho in the cell membrane of a Purkinje cell. The cell membrane is identified with arrowheads, and the Klotho-labeled particles are shown at the arrows. Also notice the immunogold particles associated with the endoplasmic reticulum (ER). N = nucleus, Nu = nucleolus.