Figure 2.

Modeling spreading inhibition and protection in a lattice of TCR. In our model, TCR are arrayed in a lattice, initially in an unmodified state (light gold circles). In a, the example of TCR A binding to an agonist is shown. This interaction results in the protection of its neighboring receptors (yellow). In b, TCR C subsequently binds to an antagonist, resulting in spreading inhibition for its neighbors (red), except for receptors already protected. Binding of an antagonist to protected receptor B has no effect. In c, binding of an agonist to inhibited receptor E has no effect, whereas binding of an agonist to protected receptor D succeeds in signaling and extending the neighborhood of protected receptors.