Table 2a.
Design | Endpoint | % positive (95%CI) | % stop early |
---|---|---|---|
Single arm, n = 37 | RR by RECIST at 6 weeks | 55.2 (53.8–56.6) | 26.3 |
Randomized, n = 20/arm | RR by RECIST at 6 weeks | 55.0 (53.6–56.4) | 3.3 |
log ratio at 6 weeks | 87.7 (86.8–88.6) | 3.9 | |
PFS-90 | 63.5 (62.2–64.9) | 11.1 | |
PFS | 68.5 (67.2–69.8) | -- | |
Randomized, n = 25/arm | RR by RECIST at 6 weeks | 63.3 (61.9–64.6) | 3.1 |
log ratio at 6 weeks | 91.9 (91.1–92.6) | 2.7 | |
PFS-90 | 70.5 (69.2–71.8) | 9.8 | |
PFS | 74.9 (73.7–76.1) | -- | |
Randomized, n = 30/arm | RR by RECIST at 6 weeks | 70.8 (69.5–72.1) | 2.9 |
log ratio at 6 weeks | 95.1 (94.5–95.7) | 1.2 | |
PFS-90 | 76.2 (75.0–77.4) | 7.2 | |
PFS | 82.6 (81.5–83.7) | -- | |
Randomized, n = 35/arm | RR by RECIST at 6 weeks | 76.0 (74.8–77.2) | 3.0 |
log ratio at 6 weeks | 96.5 (96.0–97.0) | 1.1 | |
PFS-90 | 79.0 (77.8–80.2) | 6.8 | |
PFS | 85.2 (84.2–86.2) | -- |