Figure 7.
Mice overexpressing TSLP and antigen in the skin develop aggravated asthma-like airway inflammation. (A) OVA-specific T cells are primed in K5-TGO mice. K5-TGO mice received 1 mg/ml of doxycycline for 3 weeks of treatment. Profile of DO11.10 CD4 T cells transferred into K5-TGO (left) and control (right) mice were determined in inguinal lymph node (upper) and spleen (lower). (B) Total cell counts and differential cell counts in the BAL (n = 4). (C) H&E staining of skin (upper) and PAS staining of lung (lower) from K5-TSLP/TGO mice (left) and K5-TGO mice (right). Bar, 100 μm.