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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: Cancer Res. 2012 Apr 11;72(8):2089–2099. doi: 10.1158/0008-5472.CAN-11-3019

Figure 2.

Figure 2

DT-mediated Treg depletion improves anti-tumor immunity in young but not aged tumor-bearing mice. (A–C) Young and aged C57BL/6 mice challenged with OVA expressing B16 melanoma and treated as in Fig. 1. A, Spleen OVA-specific CD8+ T cells prevalence. B, Spleen IFN-γ+ CD4+ and CD8+ T cells prevalence. (NT = no tumor, naïve controls). (D, E) Young and aged Foxp3DTR mice challenged with B16 and treated with 15 µg diphtheria toxin (Dipht. Tox)/kg or PBS. D, Tumor growth in young and aged Foxp3DTR mice. E, Prevalence of IFN-γ+ CD4+ and CD8+ T cells and OVA-specific CD8+ T cells. Values are mean ± SEM.