Table I.
Incidence of TBX3 expression in human cancers and corresponding normal tissue in the mouse. Cancers listed are those in which TBX3 has been shown to be amplified and/or overexpressed.
| Cancer | No. (%) of specimens with expression TBX3 | Method of detection | Corresponding normal expression of Tbx3 | References |
|---|---|---|---|---|
| Breast | 48/50 (96) | WB and real time PCR | Mammary epithelium and mesenchyme of developing gland | (46, 48, 55) |
| Melanoma1 | 7/12 (58) | WB | Melanocytes* | (51) |
| Pancreatic | 7 | Microarray | Developing pancreas | (57, 59, 72) |
| Cervical | 48 | Microarray | Unknown | (49) |
| Ovarian | 21/29 (70) | MALDI-Tof-MS | Not detected (unpublished) | (48) |
| Prostate | ND | GWAS | Adult prostate | (46-47, 53) |
| Colorectal | 1 | RT-PCR | Adult colon | (46, 56) |
| Liver | (70-87) | Microarray and WB | Hepatoblasts | (50, 73) |
| Gastric | 1 | Microarray | Developing stomach | (54, 72) |
| Glioblastoma | ND | Microarray | Developing CNS | (58) |
| Pheochromocytoma | ND | Microarray | Adult adrenal gland | (46, 52) |
1
melanoma cell lines in vitro
*
Also present in human melanocyte cell lines
GWAS, genome-wide association study; MALDI-Tof-MS, matrix-assisted laser desorption/ionization time of flight mass spectrometry; RT-PCR, reverse transcriptase–polymerase chain reaction; WB, western blot; ND, not determined