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The SPHARM process and analysis. On left, binarised image is pre-processed and smoothed. Centre, image is converted to surface meshes, and a spherical parameterisation is computed for the surface mesh, and meshes are aligned to establish correspondence across all surfaces. Right, group differences are computed using Hotelling T2 sample metric, and significance maps computed for each analysis, both raw uncorrected p-value maps and FDR-corrected maps.
