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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Curr Opin Chem Biol. 2012 Mar 22;16(1-2):132–141. doi: 10.1016/j.cbpa.2012.03.002

Figure 2.

Figure 2

Bacterial diterpene synthases (DTSs): (A) Mechanisms of type I and type II DTSs and (B) pathways for bacterial diterpenoid natural product biosynthesis, highlighting known bacterial type I (blue) and type II DTSs (red) that convert GGDP to diverse diterpenoid scaffolds en route to the final natural products. See Figure 1 legend for structures of the diterpenoid natural products. See Figure 3 legend for accession numbers of the type I and type II DTSs. DTSs, diterpene synthases; ent-CPP, ent-copalyl diphosphate; GGDP, geranylgeranyl diphosphate.