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Published in final edited form as: Curr Opin Chem Biol. 2012 Mar 22;16(1-2):132–141. doi: 10.1016/j.cbpa.2012.03.002

Minimum evolution trees of primary amino acid sequences from plant (green), fungal (red), and bacterial (blue) type I (A) and type II DTSs (B). The branch lengths illustrate the extent of sequence diversity found in bacterial DTSs compared with plant or fungal enzymes. The trees were constructed in Mega5.0 with a ClustalW-generated primary sequence alignment. Shown in parentheses are accession numbers. Bacterial type I DTSs: Cyc2 (BAB39207), ORF3 (BAD86798), BjKS (BAC47415), PtmT3 (ACO31279), CotB2 (BAI44338), PtmT1 (ACO31274), PtnT1 (ADD83014), Rv3378 (P_217895). Fungal type I DTSs: PaDC1 (BAG30961), ACS (BAB62102), Smcps/ks (CAP07655), Gfcps/ks (Q9UVY5), FCPS/KS (BAA22426), Orf8 (bsc8) (BAI44849), PaFS (BAF45925). Plant type I DTSs: OsKSL6 (ABH10733), OsKSL5 (ABH10732), OsKSL11 (AAZ76733), OsKSL8 (BAD34478), OsKSL10 (ABH10735), OsKSL7 (ABH10734), OsKS1 (AAQ72559), OsKSL4 (AAU05906), CmKSB (AAB39482), AtKS (AAC39443), LsKS (BAB12441), SrKS1-1 (AF097310_1), PgKS (ADB55708), PpCPS/KS (BAF61135), TPS04/GES (NP_564772), RcCS (XP_002513340), SmCPSKSL1 (AEK75338), TDC1 (AAC49310), GbLPS (AAL09965), PaTPS-Iso (AAS47690), AgAS (Q38710), PaTPS-LAS (AAS47691), PtTPS (AAX07435). Bacterial type II DTSs: Rv3377c (NP_217894), BjCPS (BAC47414), PtmT2 (ACO31276), PtnT2 (ADD83015), Orf2 (BAD86797), Cyc1 (BAB39206), Bra4 (BAG16278), PlaT2 (ABB69743). Fungal type II DTSs: FCPS/KS (BAA22426), SmCPS/KS (CAP07655), GfCPS/KS (Q9UVY5). Plant type II DTSs: OsCPS1ent (BAD42449), OsCPS2ent (Q6ET36), ZmCPS1 (AAT49065), ZmCPS2 (ADB55709), HvCPS (BAH56560), TaCPS3 (AAT70083), OsCPS4syn (NP_0010521), TaCPS1 (BAH56558), CcCLS (ADJ93862), CmCPS1 (AAD04292), CmCPS2 (AAD04923), LsCPS (BAB12440), SrCPS (AAB87091), PsCPS (AAB58822), GA1 (AAA53632), PpCPS/KS (BAF61135), PsCPSb (ADB55709), PgCPS (ADB55707), GbLPS (AAL09965), AgAS (Q38710), PtTPS-LAS (AAX07435), PaTPS-ISO (AAS47690), PaTPS-LAS (AAS47691), SmCPSKSL1 (AEK75338), TPS04/GES (NP_564772). DTSs, diterpene synthases.

Minimum evolution trees of primary amino acid sequences from plant (green), fungal (red), and bacterial (blue) type I (A) and type II DTSs (B). The branch lengths illustrate the extent of sequence diversity found in bacterial DTSs compared with plant or fungal enzymes. The trees were constructed in Mega5.0 with a ClustalW-generated primary sequence alignment. Shown in parentheses are accession numbers. Bacterial type I DTSs: Cyc2 (BAB39207), ORF3 (BAD86798), BjKS (BAC47415), PtmT3 (ACO31279), CotB2 (BAI44338), PtmT1 (ACO31274), PtnT1 (ADD83014), Rv3378 (P_217895). Fungal type I DTSs: PaDC1 (BAG30961), ACS (BAB62102), Smcps/ks (CAP07655), Gfcps/ks (Q9UVY5), FCPS/KS (BAA22426), Orf8 (bsc8) (BAI44849), PaFS (BAF45925). Plant type I DTSs: OsKSL6 (ABH10733), OsKSL5 (ABH10732), OsKSL11 (AAZ76733), OsKSL8 (BAD34478), OsKSL10 (ABH10735), OsKSL7 (ABH10734), OsKS1 (AAQ72559), OsKSL4 (AAU05906), CmKSB (AAB39482), AtKS (AAC39443), LsKS (BAB12441), SrKS1-1 (AF097310_1), PgKS (ADB55708), PpCPS/KS (BAF61135), TPS04/GES (NP_564772), RcCS (XP_002513340), SmCPSKSL1 (AEK75338), TDC1 (AAC49310), GbLPS (AAL09965), PaTPS-Iso (AAS47690), AgAS (Q38710), PaTPS-LAS (AAS47691), PtTPS (AAX07435). Bacterial type II DTSs: Rv3377c (NP_217894), BjCPS (BAC47414), PtmT2 (ACO31276), PtnT2 (ADD83015), Orf2 (BAD86797), Cyc1 (BAB39206), Bra4 (BAG16278), PlaT2 (ABB69743). Fungal type II DTSs: FCPS/KS (BAA22426), SmCPS/KS (CAP07655), GfCPS/KS (Q9UVY5). Plant type II DTSs: OsCPS1ent (BAD42449), OsCPS2ent (Q6ET36), ZmCPS1 (AAT49065), ZmCPS2 (ADB55709), HvCPS (BAH56560), TaCPS3 (AAT70083), OsCPS4syn (NP_0010521), TaCPS1 (BAH56558), CcCLS (ADJ93862), CmCPS1 (AAD04292), CmCPS2 (AAD04923), LsCPS (BAB12440), SrCPS (AAB87091), PsCPS (AAB58822), GA1 (AAA53632), PpCPS/KS (BAF61135), PsCPSb (ADB55709), PgCPS (ADB55707), GbLPS (AAL09965), AgAS (Q38710), PtTPS-LAS (AAX07435), PaTPS-ISO (AAS47690), PaTPS-LAS (AAS47691), SmCPSKSL1 (AEK75338), TPS04/GES (NP_564772). DTSs, diterpene synthases.