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. Author manuscript; available in PMC: 2013 Apr 17.
Published in final edited form as: Anal Chem. 2012 Apr 3;84(8):3682–3688. doi: 10.1021/ac300190j

Figure 2.

Figure 2

Alginate hydrogels were formed with (A) micron-scale thickness using a spincoating process (* p = 0.017; ** p < 0.001). (B) Upon treatment with alginate lyase at various concentrations (50 (red), 100 (green), 250 (purple), 1000 (orange) ug/mL, control PBS (blue) ), photocrosslinked hydrogels rapidly degraded in a dose-dependent fashion. Gels were (C) functionalized using gel-bound biotins, and an inverse trend between bulk biotin density and functionality was observed. A static cell capture assay (D) demonstrated that the functional material (blue) captured cells with an efficiency comparable (* indicates p = 0.45) to standard surface modification approaches (green), while non-functional gels (red) resisted physisorbtion of capture molecules and non-specific cell binding (** indicates p < 0.001).