Figure 1.

Silent TWIK-1 K⁺ channels conduct Na⁺ and K⁺ currents in lowered [K⁺]_o. Whole-cell currents are shown in CHO cells transfected with GFP plasmids alone (A) or with both TWIK-1 and GFP plasmids (B) before (black lines) and after (red lines) removing 5 mM extracellular K⁺. At the end of the experiments, quinine blockade confirmed TWIK-1 currents (purple line) in panel B.