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Study design. Group A study design: i.v. administration of BQ-788 (3 mg/kg) to anesthetized male SD rats undergoing saline diuresis. Group B study design: i.v. administration of incremental doses of SPP301 (0.003; 0.03; 3 mg/kg) followed by BQ-788 (3 mg/kg) to anesthetized male SD rats undergoing saline diuresis.
