Table 2.

Overview of Intra-Arterial Cell Infusion Therapy Studies in Peripheral Vascular Disease

Studies	Cell type/control	Sample size	Mean age (years)	No. of cells infused	Follow-up	Event to infusion (days)	Outcome in cell group compared with control	Reported adverse events in cell group
Ruiz-Salmeron et al.33	MNC	20	64	(100–400)×106	1 year	NM	↑ABI	None
Bartsch et al.34	MNC	8	NM	NM	2 months	NM	↑ABI	None
Walter et al.35	MNC	19	64.4	(153±78)×106	6–57 months	NM	No↑ABI;↑ulcer healing in MNC group	None
	Control	21	64.5
Van Tongeren et al.36	MNC (IA+IM route)	12	66.9	(1.23±0.49)×109	32 months	NM	↑ABI (both cell grps); IA+IM had↓amputations compared to IM only	None
	MNC (IM route)	15	69.8	(1.23±0.49)×109
Lenk et al.37	PMNC	7	69	(39±24)×106	12 weeks	NM	↑ABI	None

ABI, ankle brachial pressure index; NS, normal saline; IA, intra-arterial; IM, intra-muscular.