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. Author manuscript; available in PMC: 2012 Apr 18.
Published in final edited form as: Biochem Pharmacol. 2010 Jul 22;80(9):1450–1457. doi: 10.1016/j.bcp.2010.07.023

Figure 2.

Figure 2

Effects of liver specific expression of GPR109A or GPR109B on plasma lipids in vivo. C57BL/6 mice (n=7) were injected intraperitoneally with 1x1012 genome copies (GC) AAV2/8 GPR109A or control virus. (A) Western blot of GPR109A and ABCA1 in liver tissue from GPR109A overexpression and control mice. C57BL/6 mice were injected with 1x1012 GC AAV2/8 GPR109A or control virus IP, and 8 weeks later livers were harvested for total protein extraction. Experiments were repeated 3 times. (B) Plasma levels of total cholesterol and HDL-C after 8 weeks of transduction. Data are expressed as mean ± SEM. n=7, **P <0.01. (C) Total cholesterol FPLC Profile. C57BL/6 mice (n=8) were injected intraperitoneally with 1x1012 GC AAV2/8 GPR109B or control virus. (D) Plasma levels of total cholesterol and HDL-C after 8 weeks of transduction. Data are expressed as mean ± SEM. (E) Total cholesterol FPLC Profile.