Table 5.
Clinical characteristics and RET mutations in families with MEN2.
| Family number | Individuals analyzed/mutated | MTC/CCH | ATA risk | Age of proband at diagnosis (yr) of any tumor | Phenotype | Codon/protein substitution | PHEO (number) | HPT (number) |
| 1 | 26/11 | 8/3 | C | 42 | MEN2A/CLA | C634W | 3 | 0 |
| 2 | 7/5 | 5/0 | C | 28 | MEN2A | C634W | 2 | 0 |
| 3 | 3/1 | 1/0 | C | 43 | MEN2A/CLA | C634W | 1 | 0 |
| 4 | 4/1 | 1/0 | C | 23 | MEN2A | C634R | 1 | 1 |
| 5 | 6/5 | 5/0 | C | 38 | MEN2A | C634R | 1 | 1 |
| 6 | 7/4 | 4/0 | C | 33 | MEN2A | C634R | 1 | 0 |
| 7 | 3/1 | 1/0 | C | 26 | MEN2A | C634R | 1 | 0 |
| 8 | 6/4 | 4/0 | C | 35 | MEN2A | C634G | 2 | 0 |
| 9 | 9/5 | 5/0 | C | 29 | MEN2A | C634F | 2 | 0 |
| 10 | 9/2 | 2/0 | C | 37 | FMTC | C634Y | 0 | 0 |
| 11 | 2/2 | 2/0 | B | 40 | FMTC | C618R | 0 | 0 |
| 12 | 17/6 | 5/1 | B | 50 | FMTC | C620R | 0 | 0 |
| 13 | 11/7 | 5/2 | B | 18 | MEN2A | C620R | 2 | 0 |
| 14 | 6/2 | 1/1 | A | 40 | FMTC | V804M | 0 | 0 |
| 15 | 3/2 | 2/0 | A | 47 | FMTC | S891A | 0 | 0 |
| 16 | 2/2 | 2/0 | D | 32 | MEN2B | M918T | 1 | 0 |
| 17 | 3/1 | 1/0 | D | 14 | MEN2B | M918T | 0 | 0 |
| 18 | 3/1 | 1/0 | D | 4 | MEN2B | M918T | 0 | 0 |
| 19 | 2/2 | 2/0 | pending | 16 | MEN2A | pending | 1 | 0 |
| total | 129/63 | 56/7 | 17 | 2 |