Table 2.

Comparison of steady-state properties of total whole cell K_V, ScTx1-sensitive, ScTx1-insensitive currents and published data on the homotetrameric K_V2.1 and heterotetrameric K_V2.1/silent K_V channel currents

	Steady-State Activation		Steady-State Inactivation
	V0.5, mV	Ref.	V0.5, mV	Ref.
Control current in guinea pig DSM	−11.7 ± 0.8		−63.6 ± 1.7
ScTx1-insensitive current in guinea pig DSM	−14.5 ± 2.2		−65.3 ± 1.7
ScTx1-sensitive current in guinea pig DSM	−6.9 ± 1.4		−50.1 ± 3.7
KV current in mouse DSM	1.1 ± 1.3	56	−61.4 ± 1.2	56
ScTx1-sensitive current in rabbit urethra	−7.0 ± 5.0	37	−55.0 ± 3.0	37
KV2.1 current	−1.7	36	−30.1	36
	+12.2 ± 1.4	42	−15.9 ± 2	42
	+1.0 ± 1.0	34	−18.4 ± 2.8	6
	+7.8	12a	−28.3	12a
	+20.4	44	−34.7 ± 0.6	34
			−20.5 ± 0.9	52
KV2.1/6.2 current	−10	62	NA
KV2.1/6.3 current	−13 ± 1.8	52a	−55.6 ± 1.1	42
KV2.1/8.2 current	−2.8	12a	−30.6	12a
KV2.1/9.1 current	NA		−33.3 ± 0.2	52
KV2.1/9.2 current	NA		−35.7 ± 3.2	52
KV2.1/9.3 current	−9.5 ± 2	34	−54.8 ± 1.8	34
	+7.2	14	−47.2 ± 0.7	6
	+3.2	44	−44.9	44

Values are means ± SE of half-maximal potentials (V_0.5) of steady-state activation and inactivation from our experiments in guinea pig detrusor smooth muscle (DSM), as well as data from the literature for currents in other species and for homotetrameric K_V2.1 and heterotetrameric K_V2.1/silent K_V channel currents. NA, not available.