Table 3.
Comparison of time constants of total whole cell KV, ScTx1-sensitive, and ScTx1-insensitive currents and published data on the homotetrameric KV2.1 and heterotetrameric KV2.1/silent KV channel currents
| Time Constant of Activation |
Time Constant of Inactivation |
|||
|---|---|---|---|---|
| τ, ms | Ref. | τ, s | Ref. | |
| Control current in guinea pig DSM | 25.5 ± 2.1 (+40 mV) | 5.4 ± 0.8 (+40 mV) | ||
| ScTx1-insensitive current in guinea pig DSM | 23.7 ± 1.2 (+40 mV) | 5.4 ± 1.3 (+40 mV) | ||
| ScTx1-sensitive current in guinea pig DSM | 35.3 ± 3.6 (+40 mV) | 5.9 ± 1.6 (+40 mV) | ||
| KV2.1 current | 15.6 ± 0.9 (+30 mV) | 52 | 7.0 (+40 mV) | 34 |
| 21 ± 1 (+20 mV) | 34 | |||
| 7 (+10 mV) | 44 | |||
| 74 ± 3 (−10 mV) | 34 | |||
| 68.4 ± 6.8 (+30 mV) | 42 | |||
| KV current in mouse DSM | 29.9 ± 2.0 (+30 mV) | 56 | 3.4 ± 0.2 (+20 mV) | 56 |
| KV2.1/KV6.3 | 22.6 ± 3.2 (+30 mV) | 42 | NA | |
| KV2.1/9.1 current | 14.3 ± 0.8 (+30 mV) | 52 | NA | |
| KV2.1/9.2 current | 20.3 ± 1.3 (+30 mV) | 52 | NA | |
| KV2.1/9.3 current | 20.1 ± 1 (+20 mV) | 34 | 16.2 ± 1.8 (+40 mV) | 34 |
| 79 ± 2 (−10 mV) | 34 | |||
| 4.9 (+10 mV) | 44 | |||
| 7.3 ± 0.6 (+60 mV) | 31a | |||
Values are means ± SE of the time constants (τ) of activation and inactivation (with action potential given in parentheses) from our experiments in guinea pig DSM, as well as data from the literature for homotetrameric KV2.1 and heterotetrameric KV2.1/silent KV channel currents.