Table 4.

Effects of ScTx1 on DSM contraction parameters under conditions of KCl- or carbachol-induced membrane depolarization

	Amplitude, %change	Force, %change	Frequency, %change	Tone, %change
Carbachol (1 μM)-induced contractions	136.8 ± 14.70*	106.0 ± 9.8	100.1 ± 3.3	97.8 ± 1.8
K+ (20 mM)-induced contractions	108.3 ± 10.6	105.9 ± 11.7	92.7 ± 6.7	99.9 ± 2.4

Values are means ± SE of %change in DSM contraction parameters under conditions of membrane depolarization induced by 1 μM carbachol or 20 mM KCl (K⁺) in the presence of 100 nM ScTx1. Carbachol results are from 9 DSM strips obtained from 9 guinea pigs; KCl results are from 12 DSM strips obtained from 10 guinea pigs.

^*P < 0.05, ScTx1 slightly increased phasic contraction amplitude only under conditions of depolarization with carbachol. ScTx1 had no other statistically significant effect on DSM contraction parameters.