Figure 4. IL-1RI signalling is critical for neutrophil and macrophage recruitment following S. aureus infection.
IL-1RI KO and WT mice (n = 8–10 per group) received intracerebral injections of S. aureus (7×103 cfu) and were killed at either 12 or 18 h post-infection, whereupon neutrophils, macrophages and microglia were quantified by FACS analysis. Results are expressed as the percentage of each cell population normalized to WT values from three independent experiments (means±S.E.M.) with significant differences between IL-1RI KO and WT animals denoted by asterisks (*P<0.05).