Figure 6. Microglial/macrophage activation during acute brain abscess development is less pronounced in IL-1RI KO mice.

IL-1RI KO and WT mice received intracerebral injections of S. aureus (10³ cfu) to extend survival of the former. Tissues were collected from animals at day 3 following infection for immunofluorescence staining and confocal microscopy for Iba-1 (green) and caspase 1 (red; magnification ×20). Arrows denote Iba-1⁺ microglia/macrophages that express caspase 1. Results are representative of tissues collected from six individual animals per group.